International Journal of Pediatric Otorhinolaryngology Extra
Volume 1, Issue 1 , Pages 22-26, March 2006

Posttransplantation lymphoproliferative disorder of the paranasal sinuses in a child

  • Frederick S. Rosen

      Affiliations

    • Department of Otolaryngology – Head and Neck Surgery, Lucile Packard Children's Hospital/Stanford University Medical Center, 801 Welch Road, Route 5739, Palo Alto, CA 94304, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 650 736 1455; fax: +1 650 498 2734.
  • ,
  • David Bingham

      Affiliations

    • Department of Pathology, 300 Pasteur Drive, Lane 235, Stanford, CA 94305-5324, USA
  • ,
  • Kay W. Chang

      Affiliations

    • Department of Otolaryngology – Head and Neck Surgery, Lucile Packard Children's Hospital/Stanford University Medical Center, 801 Welch Road, Route 5739, Palo Alto, CA 94304, USA

Received 19 August 2005; received in revised form 18 November 2005; accepted 25 November 2005.

Summary 

Posttransplantation lymphoproliferative disorder (PTLD) represents an often fatal complication of chronic immunosuppression following solid organ or bone marrow transplantation. PTLD in the head and neck is uncommon and generally involves lymphoproliferation in Waldeyer's ring, cervical lymphadenopathy, or both. This unusual case of PTLD involving the paranasal sinuses in a child illustrates the difficulty in distinguishing PTLD from invasive fungal sinusitis. Promptly establishing the correct diagnosis via biopsy is critical to the successful management of such a patient.

Keywords: Posttransplantation lymphoproliferative disorder, T-cell, Paranasal sinuses, Child

 

PII: S1871-4048(05)00011-0

doi:10.1016/j.pedex.2005.11.005

International Journal of Pediatric Otorhinolaryngology Extra
Volume 1, Issue 1 , Pages 22-26, March 2006