International Journal of Pediatric Otorhinolaryngology Extra
Volume 3, Issue 2 , Pages 61-65 , March 2008

Case study: Langerhans’ cell histiocytosis (LCH)

  • Nico Jonas

      Affiliations

    • Division of Otolaryngology, University of Cape Town Medical School, South Africa
    • Corresponding Author InformationCorresponding author at: Division of Otolaryngology, University of Cape Town Medical School, H53 Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa. Tel.: +27 21 4066420; fax: +27 21 4488865.
    • ,
  • Wakisa Mulwafu

      Affiliations

    • Division of Otolaryngology, University of Cape Town Medical School, South Africa
    • ,
  • Sally-Anne Khosa

      Affiliations

    • Department of Anatomical Pathology, Red Cross Children's Hospital, South Africa
    • ,
  • Marc Hendricks

      Affiliations

    • Haematology/Oncology Service, Red Cross Children's Hospital, South Africa

Received 30 May 2007 ,Accepted 4 October 2007.

  • Image Result

    High-power view demonstrating a proliferation of Langerhans cells. Scattered eosinophils are present in the background.

    High-power view demonstrating a proliferation of Langerhans cells. Scattered eosinophils are present in the background.

  • Image Result

    Histiocytes, some of which are multinucleate, are also present in the background and these are highlighted well on the CD 68 stain (upper left-hand corner), high-power view.

    Histiocytes, some of which are multinucleate, are also present in the background and these are highlighted well on the CD 68 stain (upper left-hand corner), high-power view.

  • Image Result

    The Langerhans cells show strongly positive with the CD1a stain, high-power view.

    The Langerhans cells show strongly positive with the CD1a stain, high-power view.

  • Image Result

    Tumour cells are also positive for the s100 stain, high-power view.

    Tumour cells are also positive for the s100 stain, high-power view.

  • Image Result

    CT scan post surgery and pre-treatment showing temporal bone resorption with associated soft tissue involvement on the right side.

    CT scan post surgery and pre-treatment showing temporal bone resorption with associated soft tissue involvement on the right side.

  • Image Result

    Follow up CT scan showing re-ossification and remodelling of the right temporal bone.

    Follow up CT scan showing re-ossification and remodelling of the right temporal bone.

PII: S1871-4048(07)00081-0

doi: 10.1016/j.pedex.2007.10.004

International Journal of Pediatric Otorhinolaryngology Extra
Volume 3, Issue 2 , Pages 61-65 , March 2008

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