Young child with cystic fibrosis and sinonasal destructive polyposis which resolved incidentally with oral antifungals

Summary 

Cystic fibrosis (CF) affects between 1 in 2000 and 1 in 4500 children of European descent [R.S. Mendelsohn, B.M. Cohen. Otorhinolaryngologic aspects of cystic fibrosis. Archives of Otolaryngology 79 March (1964) 312–17]. There have been few reported cases of fungal sinus infections in patients with CF [S.K. Wise, T.T. Kingdom, L. McKean, J.M. DelGaudio, G. Venkatraman. Presence of fungus in sinus cultures of cystic fibrosis patients. American Journal of Rhinology 19 January–February (1) (2005) 47–51]. We report a unique case of a young male with CF presenting with severe destructive sinonasal polyposis, which was refractory to all treatment until he was treated for a concomitant fungal bronchopulmonary infection.

Keywords: Sinonasal polyposis, Cystic fibrosis, Allergic fungal sinusitis, Proptosis