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Volume 6, Issue 1 , Pages 9-12 , January 2011

Management and treatment of a sialoblastoma of the submandibular gland in a neonate

Carine Fuchsmann
- Department of Pediatric ENT and Head and Neck Surgery, HFME, Bd Pinel, F-69600 Bron, France
- Department of ENT and Head and Neck Surgery, Hopital Edouard Herriot, Place d’Arsonval, F-69003 Lyon, France
- Corresponding author at: Hopital Femme-Mère Enfant, Service d’ORL pédiatrique et chirurgie cervico-faciale, 59 Bd Pinel, 69600 Bron, France. Tel.: +33 687095836.
Loic Viremouneix
- Department of Pediatric Radiology, HFME, Bd Pinel, F-69600 Bron, France
Sophie Collardeau-Frachon
- Department of Histopathology, HFME, Bd Pinel, F-69600 Bron, France
Sonia Ayari-Khalfallah
- Department of Pediatric ENT and Head and Neck Surgery, HFME, Bd Pinel, F-69600 Bron, France
- Department of ENT and Head and Neck Surgery, Hopital Edouard Herriot, Place d’Arsonval, F-69003 Lyon, France
Raymonde Bouvier
- Department of Histopathology, HFME, Bd Pinel, F-69600 Bron, France
Laurent Guibaud
- Department of Pediatric Radiology, HFME, Bd Pinel, F-69600 Bron, France
Patrick Froehlich
- Department of Pediatric ENT and Head and Neck Surgery, HFME, Bd Pinel, F-69600 Bron, France
- Department of ENT and Head and Neck Surgery, Hopital Edouard Herriot, Place d’Arsonval, F-69003 Lyon, France

Received 6 November 2009 ,Revised 1 December 2009 ,Accepted 2 December 2009.

T2-weighted foetal MRI showing the large left cervical tumor: coronal (A) and saggital (B) views.

T2-weighted foetal MRI showing the large left cervical tumor: coronal (A) and saggital (B) views.
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Photography of the 3 days old girl showing the large swelling going from the left parotid region to the left submandibular region.

Photography of the 3 days old girl showing the large swelling going from the left parotid region to the left submandibular region.
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(A) T2-weighted coronal view showing an intermediate signal intensity of the tumor. (B) Axial post-gadolinium T1-weighted images showing a rather high contrast enhancement of the mass.

(A) T2-weighted coronal view showing an intermediate signal intensity of the tumor. (B) Axial post-gadolinium T1-weighted images showing a rather high contrast enhancement of the mass.
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Intraoperative view showing the tumor that is about to be removed in monobloc with the submandibular gland (white arrow).

Intraoperative view showing the tumor that is about to be removed in monobloc with the submandibular gland (white arrow).
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Gross findings: the tumor was firm, multilobulated, orange or beige, without necrosis.

Gross findings: the tumor was firm, multilobulated, orange or beige, without necrosis.
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Microscopic features (hematoxylin eosin saffron×25): Islands and nests of epithelial cells with basaloid appearance separated by bands of fibrous stroma.

Microscopic features (hematoxylin eosin saffron×25): Islands and nests of epithelial cells with basaloid appearance separated by bands of fibrous stroma.
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Immunohistochemical study: Ki67 expression is around 20–30%, mostly in periphery of the nests.

Immunohistochemical study: Ki67 expression is around 20–30%, mostly in periphery of the nests.
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