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Volume 6, Issue 2 , Pages 104-106 , March 2011

Follicular dendritic cell sarcoma presenting in the submandibular region of an 11-year-old

Amanda L. Silver
- Department of Otolaryngology, Division of Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, United States
- Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, United States
- Corresponding author at: Department of Otolaryngology, Division of Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, United States. Tel.: +1 617 573 3654; fax: +1 617 573 3939.
William C. Faquin
- Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, United States
Daniel G. Deschler
- Department of Otolaryngology, Division of Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, United States
- Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, United States

Received 22 March 2010 ,Revised 26 May 2010 ,Accepted 31 May 2010.

Axial post-gadolinium T1-weighted MR image shows uniform enhancement of the gland and tumor and extension of the tumor along the buccal margin of the mandible into the subcutaneous fat.

Axial post-gadolinium T1-weighted MR image shows uniform enhancement of the gland and tumor and extension of the tumor along the buccal margin of the mandible into the subcutaneous fat.
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FDCS showing neoplastic cells infiltrating skeletal muscle (H&E, ×600).;

FDCS showing neoplastic cells infiltrating skeletal muscle (H&E, ×600).
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The tumor cells exhibit a syncytial, swirling growth pattern (H&E, ×400).;

The tumor cells exhibit a syncytial, swirling growth pattern (H&E, ×400).
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The neoplastic cells have eosinophilic cytoplasm, indistinct cell borders, and oval to elongated nuclei. Rare mitoses and occasional multinucleate cells are present (H&E, ×600).;

The neoplastic cells have eosinophilic cytoplasm, indistinct cell borders, and oval to elongated nuclei. Rare mitoses and occasional multinucleate cells are present (H&E, ×600).
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The tumor is immunohistochemically positive for the follicular dendritic cell marker CD23 (×600).

The tumor is immunohistochemically positive for the follicular dendritic cell marker CD23 (×600).
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